Biochem/physiol Actions

Primary TargetGAT-1

General description

A potent uptake inhibitor highly selective for GABA Transport-1 (IC₅₀ = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther.302, 1168.r>Hu, Q., et al. 1997. Brain Res.753,260.Suzdak, P., et al., 1995. Epilepsia.36, 612.Andersen, E., et al., 1993. J. Med. Chem.36, 1716.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)